A free resource for high quality structural information of WD40 proteins

Examples - UniProt ID: WDR5_HUMAN; UniProt AC: P61964; Gene: WDR5; Entrez ID: 11091; Organism: Human


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WDSPdb is a free and comprehensive resource to provide accurate structure predictions and featured sites annotations specifically for WD40 domains based on the powerful tool WD40-repeat protein Structures Predictor (WDSP). It has recorded about 600,000 predicted WD40 proteins from 4426 species.

WD40-repeat protein Structure Predictor (WDSP)

is developed to accurately identify WD40 repeats and predict the secondary structures of WD40 domains as well as structural and functional features based on their primary sequences.

WD40-repeat Domains

are one of the most popular interactors in protein-protein interaction (PPI) networks and play versatile roles in fundamental biological processes.

Hydrogen Bond Network

is a special structure feature composed by Asp-His-Ser/Thr-Trp which is widely and uniquely presented in WD40 proteins. They help the WD40 repeat folding and contribute to the structure stability.

Potential Hotspots on Top Surface

are specific types of residues protruded on the top face of the WD40 domains. They may participate in the interactions on the top face.

Getting Started

Confidence Category

Data Source

Citiations and publications:

If you use the data of WDSPdb or the WDSP in you research, please cite the following papers:

Wang, Y., Hu, X.J., Zou, X.D., Wu, X.H., Ye, Z.Q. and Wu, Y.D. (2015) WDSPdb: a database for WD40-repeat proteins. Nucleic Acids Res, 43 , D339-344. [PMID: 25348404]

Wang, Y., Jiang, F., Zhuo, Z., Wu, X.H., Wu, Y.D. (2013). A Method for WD40 Repeat Detection and Secondary Structure Prediction. PLoS ONE , 8(6) , e65705. [PMID: 23776530]

Wu, X.H., Wang, Y., Zhuo, Z.,Jiang, F., Wu, Y.D. (2012). Identifying the hotspots on the top faces of WD40-repeat proteins from their primary sequences by beta-bulges and DHSW tetrads. PLoS ONE , 7(8) , e43005. [PMID: 22916195]